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New Ti-Mo-Si materials for bone prosthesis applications

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dc.contributor.author Vereștiuc, Liliana
dc.contributor.author Spătaru, Mihaela-Claudia
dc.contributor.author Bălțatu, Mădălina-Simona
dc.contributor.author Butnaru, Maria
dc.contributor.author Solcan, Carmen
dc.contributor.author Sandu, Andrei-Victor
dc.contributor.author Voiculescu, Ionelia
dc.contributor.author Geantă, Victor
dc.contributor.author Vizureanu, Petrică
dc.date.accessioned 2024-05-21T10:52:57Z
dc.date.available 2024-05-21T10:52:57Z
dc.date.issued 2020-11-07
dc.identifier.citation Verestiuc, Liliana, Mihaela-Claudia Spataru, Madalina Simona Baltatu, Maria Butnaru, Carmen Solcan, Andrei Victor Sandu, Ionelia Voiculescu, Victor Geanta, and Petrica Vizureanu. 2021. “New Ti–Mo–Si Materials for Bone Prosthesis Applications.” Journal of the Mechanical Behavior of Biomedical Materials/Journal of Mechanical Behavior of Biomedical Materials 113 (January): 104198–98. https://doi.org/10.1016/j.jmbbm.2020.104198. en_US
dc.identifier.issn 1878-0180
dc.identifier.issn https://doi.org/10.1016/j.jmbbm.2020.104198
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S1751616120307402
dc.identifier.uri https://repository.iuls.ro/xmlui/handle/20.500.12811/3943
dc.description.abstract Several newly obtained titanium alloys were characterized in order to evaluate the biocompatibility and their possible application as implants. For improvement of the performances of the TiMo alloys compared to other alloys, silicon was added, targeting good mechanical and technological properties, avoiding the toxic effects for human body. Titanium is very used in medical applications, due to their extremely low toxicity and good chemical stability in different body fluids. Four Ti15MoxSi (where x = 0, 0.5, 0.75, 1.0 wt %), alloys were developed and investigated regarding microstructure, mechanical, chemical and biological behavior (in vitro and in vivo evaluation). By increasing the Si content from 0 to 1% wt., the mechanical properties of the Ti15Mo alloys were significantly improved. By increasing the Si content from 0 to 1% wt., the mechanical properties of the Ti15Mo alloys were significantly improved (about 50%) from 44.50 GPa to 19.81 GPa modulus of elasticity and the hardness values 361.28 to 188.52 HV. The cytocompatibility assessment on human line osteoblasts indicated good cell-material interactions and in vivo tests indicated a successful osseointegration, the surrounding newly bone being formed without any significant inflammatory reaction. Expression of osteopontin in the peri-implant area highlights the presence of osteogenesis and bone mineralization. Metalloproteinase-2 (gelatinase A) and metallopeptidase-9 (gelatinase B) overexpression in osteoblasts, osteoclasts and osteocytes represent the markers of normal bone remodeling. All these results suggest that the TiMoSi alloys are promising materials for orthopedics devices, since mechanical properties and biocompatibility offer conditions for applying them as biomaterial. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights Elsevier
dc.subject Titanium en_US
dc.subject Osseointegration en_US
dc.subject Cytocompatibility en_US
dc.subject TiMoSi alloys en_US
dc.subject Casting en_US
dc.title New Ti-Mo-Si materials for bone prosthesis applications en_US
dc.type Article en_US
dc.author.affiliation Liliana Verestiuc, Maria Butnaru, Grigore T. Popa University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Biomedical Sciences Department, 9-13 Kogalniceanu Street, 700454, Iasi, Romania
dc.author.affiliation Mihaela-Claudia Spataru, Carmen Solcan, Ion Ionescu de la Brad" University of Agricultural Sciences and Veterinary Medicine Iasi, 3 Mihail Sadoveanu Street, 700490, Iasi, Romania
dc.author.affiliation Madalina Simona Baltatu, Andrei Victor Sandu, Petrica Vizureanu, Gheorghe Asachi” Technical University of Iasi, Faculty of Materials Science and Engineering, 41 “D. Mangeron” Street, 700050, Iasi, Romania
dc.author.affiliation Andrei Victor Sandu, Romanian Inventors Forum, Str. Sf.P.Movila 3, Iasi, 700089, Romania
dc.author.affiliation Ionelia Voiculescu, Victor Geanta, Politehnica University of Bucharest, Splaiul Independenței 313, Bucharest, Romania
dc.publicationName Journal of the Mechanical Behavior of Biomedical Materials
dc.volume 113
dc.publicationDate 2021


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