dc.contributor.author |
Vereștiuc, Liliana |
|
dc.contributor.author |
Spătaru, Mihaela-Claudia |
|
dc.contributor.author |
Bălțatu, Mădălina-Simona |
|
dc.contributor.author |
Butnaru, Maria |
|
dc.contributor.author |
Solcan, Carmen |
|
dc.contributor.author |
Sandu, Andrei-Victor |
|
dc.contributor.author |
Voiculescu, Ionelia |
|
dc.contributor.author |
Geantă, Victor |
|
dc.contributor.author |
Vizureanu, Petrică |
|
dc.date.accessioned |
2024-05-21T10:52:57Z |
|
dc.date.available |
2024-05-21T10:52:57Z |
|
dc.date.issued |
2020-11-07 |
|
dc.identifier.citation |
Verestiuc, Liliana, Mihaela-Claudia Spataru, Madalina Simona Baltatu, Maria Butnaru, Carmen Solcan, Andrei Victor Sandu, Ionelia Voiculescu, Victor Geanta, and Petrica Vizureanu. 2021. “New Ti–Mo–Si Materials for Bone Prosthesis Applications.” Journal of the Mechanical Behavior of Biomedical Materials/Journal of Mechanical Behavior of Biomedical Materials 113 (January): 104198–98. https://doi.org/10.1016/j.jmbbm.2020.104198. |
en_US |
dc.identifier.issn |
1878-0180 |
|
dc.identifier.issn |
https://doi.org/10.1016/j.jmbbm.2020.104198 |
|
dc.identifier.uri |
https://www.sciencedirect.com/science/article/pii/S1751616120307402 |
|
dc.identifier.uri |
https://repository.iuls.ro/xmlui/handle/20.500.12811/3943 |
|
dc.description.abstract |
Several newly obtained titanium alloys were characterized in order to evaluate the biocompatibility and their possible application as implants. For improvement of the performances of the TiMo alloys compared to other alloys, silicon was added, targeting good mechanical and technological properties, avoiding the toxic effects for human body. Titanium is very used in medical applications, due to their extremely low toxicity and good chemical stability in different body fluids. Four Ti15MoxSi (where x = 0, 0.5, 0.75, 1.0 wt %), alloys were developed and investigated regarding microstructure, mechanical, chemical and biological behavior (in vitro and in vivo evaluation). By increasing the Si content from 0 to 1% wt., the mechanical properties of the Ti15Mo alloys were significantly improved. By increasing the Si content from 0 to 1% wt., the mechanical properties of the Ti15Mo alloys were significantly improved (about 50%) from 44.50 GPa to 19.81 GPa modulus of elasticity and the hardness values 361.28 to 188.52 HV. The cytocompatibility assessment on human line osteoblasts indicated good cell-material interactions and in vivo tests indicated a successful osseointegration, the surrounding newly bone being formed without any significant inflammatory reaction. Expression of osteopontin in the peri-implant area highlights the presence of osteogenesis and bone mineralization. Metalloproteinase-2 (gelatinase A) and metallopeptidase-9 (gelatinase B) overexpression in osteoblasts, osteoclasts and osteocytes represent the markers of normal bone remodeling. All these results suggest that the TiMoSi alloys are promising materials for orthopedics devices, since mechanical properties and biocompatibility offer conditions for applying them as biomaterial. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.rights |
Elsevier |
|
dc.subject |
Titanium |
en_US |
dc.subject |
Osseointegration |
en_US |
dc.subject |
Cytocompatibility |
en_US |
dc.subject |
TiMoSi alloys |
en_US |
dc.subject |
Casting |
en_US |
dc.title |
New Ti-Mo-Si materials for bone prosthesis applications |
en_US |
dc.type |
Article |
en_US |
dc.author.affiliation |
Liliana Verestiuc, Maria Butnaru, Grigore T. Popa University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Biomedical Sciences Department, 9-13 Kogalniceanu Street, 700454, Iasi,
Romania |
|
dc.author.affiliation |
Mihaela-Claudia Spataru, Carmen Solcan, Ion Ionescu de la Brad" University of Agricultural Sciences and Veterinary Medicine Iasi, 3 Mihail Sadoveanu Street, 700490, Iasi, Romania |
|
dc.author.affiliation |
Madalina Simona Baltatu, Andrei Victor Sandu, Petrica Vizureanu, Gheorghe Asachi” Technical University of Iasi, Faculty of Materials Science and Engineering, 41 “D. Mangeron” Street, 700050, Iasi, Romania |
|
dc.author.affiliation |
Andrei Victor Sandu, Romanian Inventors Forum, Str. Sf.P.Movila 3, Iasi, 700089, Romania |
|
dc.author.affiliation |
Ionelia Voiculescu, Victor Geanta, Politehnica University of Bucharest, Splaiul Independenței 313, Bucharest, Romania |
|
dc.publicationName |
Journal of the Mechanical Behavior of Biomedical Materials |
|
dc.volume |
113 |
|
dc.publicationDate |
2021 |
|